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In normal wound healing, platelets migrate from the blood into a
wound site, where they serve as a primary source of growth factors, chemokines and cytokines that regulate biological responses critical
for effective wound healing. Platelet factor 4 (PF-4), vascular
endothelial growth factor (VEGF), transforming growth factor beta (TGF-β),
epidermal growth factor (EGF), and fibroblast growth factor (FGF)
are some examples of proteins released by platelets to control the
migration of cells, the formation of new blood vessels
(angiogenesis), cell growth, cell differentiation and deposition of
new tissue. In chronic wounds and other tissues where blood supply
may be low, the delivery of platelets is often impeded so adequate
concentrations of growth factors, cytokines and chemokines are not
released and wound healing stalls. In these cases, a patients’ own
platelet rich plasma can be activated to generate a fibrin rich gel
that serves as a rich source of growth factors, cytokines and
chemokines to re-establish balance in the wound bed. The PRP System
harnesses the patient’s natural healing processes to providing
growth factors, chemokines and cytokines known to promote
angiogenesis and to regulate cell growth and formation of new
tissue. PRP technology restores the balance in the wound environment
to transform a non-healing wound to a wound that heals naturally.
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