Autologous platelet-rich plasma (PRP) has become a popular clinical treatment in a variety of soft tissue and hard tissue applications. Clinicians use PRP to harvest the platelets’ natural ability to promote hemostasis and to release cytokines into the wound bed with hopes of stimulating the rate of healing and improving tissue quality. Platelet-derived growth factor, transforming growth factor β1, vascular endothelial growth factor, basic fibroblast growth factor, epidermal growth factor, insulin-like growth factor and connective tissue growth factor are among the more notable cytokines released from platelets. In orthopedics, PRP is most successful when paired with the appropriate matrices and/or cell therapies for optimal results. Given the data published to date, PRP appears to be a powerful autologous therapy for surgeons looking to enhance bone and soft tissue formation.
For more information: Virginia Cartilage Institute