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Autologous platelet-rich plasma (PRP) has become a popular clinical
treatment in a variety of soft tissue and hard tissue applications.
Clinicians use PRP to harvest the platelets’ natural ability to
promote hemostasis and to release cytokines into the wound bed with
hopes of stimulating the rate of healing and improving tissue
quality. Platelet-derived growth factor, transforming growth factor
β1, vascular endothelial growth factor, basic fibroblast growth
factor, epidermal growth factor, insulin-like growth factor and
connective tissue growth factor are among the more notable cytokines
released from platelets. In orthopedics, PRP is most successful when
paired with the appropriate matrices and/or cell therapies for
optimal results. Given the data published to date, PRP appears to be
a powerful autologous therapy for surgeons looking to enhance bone
and soft tissue formation.
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