Chronic wounds caught in a prolonged inflammatory phase are linked to infection, tissue damage by free radicals & proteases,4-6 and a cycle of wound deterioration maintained by inflammatory mediators.1,7,8   Chronic ulcers are often accompanied by edema, ischemia, or lack of perfusion, impeding the normal delivery of cells and nutrients to the wound bed.9   Imbalances in the relative levels of growth factors, cytokines, and chemokines contribute to chronic wounds. This complexity may explain why single growth factors and growth factor concentrates are incomplete solutions in the management of chronic wounds.7

AutoloGel System: Restore the Balance
A healthy wound needs a moist environment and adequate delivery of nutrients and cellular sources of growth factors, cytokines and chemokines to heal itself naturally. Imbalances in the relative levels of growth factors, cytokines and chemokines contribute to chronic wounds. Newer clinical approaches such as AutoloGel PRP gel can be used to re-establish the balanced environment missing in chronic wounds.

The AutoloGel System harnesses the patient's natural healing processes: The patient's own blood derived growth factors, cytokines, and chemokines delivered as a proprietary formulation to the prepared wound bed   Re-establishes a natural, balanced wound environment   Non-concentrated, physiologically relevant formulation supports natural healing of chronic wounds

1 Diegelmann R, Evans MC. Wound Healing: An Overview of Acute, Fibrotic and Delayed Healing. 2004. Frontiers in Bioscience 9:283-289

4 Mast BA, Schultz GS. Interactions of cytokines, growth factors, and proteases in acute and chronic wounds. Wound Repair Regen 1996; 4(4): 411-20

5 James TJ, Hughes MA,

Cherry GW, Taylor RP. Evidence of oxidative stress in chronic venous ulcers. Wound Repair Regen 2003; 11(3): 172-6

6 Moseley R, Hilton JR, Waddington RJ, Harding KG, Stephens P, Thomas DW. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair Regen 2004; 12(4): 419-29

7 Goldman R. Growth Factors and Chronic Wound Healing: Past, Present, and Future. 2004 Adv. Skin Wound Care 17:24-35

8 Ochoa O, Torres FM, Shireman PK. Chemokines and diabetic wound healing.   Vascular 15(6): 350-355. 2007

9 Sussman C, Bates-Jensen B. Wound Care, A collaborative practice manual for health professionals. 2007 3rd edition Lippincott Williams and Wilkins. pp.33-34