Cytomedix  Taking the Science of Wound Repair  ...and Using It to Treat Wounds
About UsAutologelPatientsProfessionalsInvestorsContact Info

Professionals
Clinical References   

Home


Published Clinical References

Over two decades of research has been conducted and published in peer-review medical journals on the use of autologous multiple growth factors in the management of wounds. Prospective controlled studies, retrospective studies on wound healing and amputation prevention, and cost effectiveness studies have been published. While the names of the processes and the techniques have changed and advanced through the years, the principles of use of autologous multiple growth factors for topical application to wounds remain the same. The following list provides published articles describing outcomes documented in more than 30,000 patients.

Review Articles

Everts PA, Knape, JT, Weibrich G, Schonberger JP,, Hoffman J, Overdest EP, Box H, van Zundert A, Platelet-rich Plasma and Platelet Gel: A Review, JECT:2006;38; 174-187:
 
Prospective Studies


Driver V, Hanft J, Fylling C, Beriou J, AutoloGel™ Diabetic Foot Ulcer Study Group. A Prospective, Randomized, Controlled Trial of Autologous Platelet-Rich Plasma Gel versus Control for the Treatment of Diabetic Foot Ulcers. Ostomy/Wound Management. 2006; 52(6): 68-87.

Saldalamacchia G, Lapice E, Cuomo V, De Feo E, D’Agostino E, Rivellese AA, Vaccaro O, A controlled study of the use of autologous platelet gel for the treatment of diabetic foot ulcers. Nutr Metab Cardiovasc Dis. 2004 Dec; 14(6):395-6

Holloway GA, Steed DL, DeMarco MJ, et al. A randomized, controlled dose response trial of activated platelet supermatant, topical CT-102 in chronic, nonhealing, diabetic wounds. Wounds. 1993;5:160-168.

Steed DL, Goslen JB, Holloway GA, et al. Randomized, double blind trial in healing of chronic diabetic foot ulcers: CT-102 activated platelet supernatant, topical versus placebo. Diabetes Care. 1992;15:1598-1604.

Knighton DR, Ciresi K, Fiegel VD, et al. Stimulation of repair in chronic nonhealing cutaneous ulcers: a prospectively randomized blinded trial using platelet-derived wound healing formula. Surg Gynecol Obstet. 1990;170:56-60.

Atri SC, Misra J, Bisht D, et al. Use of homologous platelet factors in achieving total healing of recalcitrant skin ulcers. Surgery. 1990;108: 508-512


Retrospective Studies
 
Margolis DJ, Kantor J, Santanna J, et al. Effectiveness of Platelet Releasate for the Treatment of Diabetic Neuropathic Foot Ulcers. Diabetes Care. 2001;24:483-488.

Fylling CP, Baxter CR, Bennett KG, et al. Multi-center clinical review: Using autologous platelet gel for the treatment of diabetic plantar wounds. Diabetes. 2001(S2);50:229A.

Glover JL, Weingarten MS, Buchbinder DS, et al. A four-year multicenter retrospective study of topical multiple growth factor therapy for chronic wounds. Adv Wound Care. 1997;10(1):27-32.

Keyser, JE. Diabetic wound healing and limb salvage in an outpatient wound care program. South Med Jour. 1993;86:311-317.

Fylling, CP. A five center study of diabetic wound healing in comprehensive wound management programs. Diabetes. 1992(S);41:82A

Knighton DR, Fylling CP, Fiegel VD, et al. Amputation prevention in an independently reviewed at-risk diabetic population using a comprehensive wound care protocol. Amer J Surg. 1990;160:466-472.

Fylling CP, Knighton DR, Gordinier RH. The use of a comprehensive wound care protocol including topical growth factor therapy in treatment of diabetic neuropathic ulcers. In: Ward J and Goto Y. Diabetic Neuropathy. New York: John Wiley & Sons; 1990:567-578.

Doucette MM, Fylling CP, Knighton DR. Amputation Prevention in a high-risk population through a comprehensive wound healing protocol. Arch Phys Med Rehabil. 1989;70:780-785.

Knighton DR, Fylling CP, Doucette MM. Wound healing and amputation in a high-risk diabetic population. Wounds. 1989;2:107-114.

Knighton DR, Ciresi KF, Fiegel VD, et al. Classification and treatment of chronic nonhealing wounds: successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg. 1986;3:322-330..

Cost Effectiveness Studies

Bentkover JF, Champion AH. Economic evaluation of alternative methods of treatment for diabetic foot ulcer patients: cost effectiveness of platelet releasate and wound care clinics. Wounds. 1993;5:207-215.

Fylling CP, McKeown PC. Cost and healing efficacy of treating diabetic foot ulcers in a comprehensive wound management program with growth factor therapy. Diabetes. 1990(S);39:18A.


AutoloGel System - for preperation of Platelet Rich Plasma Gel      
Back to top  

[
HOME]   [ABOUT US]   [AUTOLOGEL]   [PATIENTS]   [PROFESSIONALS]   [INVESTORS]   [CONTACT INFO]