Published Clinical References
Over two decades of research has been conducted and published in
peer-review medical journals on the use of autologous multiple
growth factors in the management of wounds. Prospective controlled
studies, retrospective studies on wound healing and amputation
prevention, and cost effectiveness studies have been published.
While the names of the processes and the techniques have changed and
advanced through the years, the principles of use of autologous
multiple growth factors for topical application to wounds remain the
same. The following list provides published articles describing
outcomes documented in more than 30,000 patients.
Review Articles
Everts PA,
Knape, JT, Weibrich G, Schonberger JP,, Hoffman J, Overdest EP, Box
H, van Zundert A, Platelet-rich Plasma and Platelet Gel: A Review,
JECT:2006;38; 174-187:

Prospective Studies
Driver V, Hanft J, Fylling C, Beriou J, AutoloGel™ Diabetic Foot Ulcer
Study Group. A Prospective, Randomized, Controlled Trial of Autologous
Platelet-Rich Plasma Gel versus Control for the Treatment of Diabetic
Foot Ulcers. Ostomy/Wound Management. 2006; 52(6): 68-87.

Saldalamacchia G, Lapice E, Cuomo V, De Feo E, D’Agostino E,
Rivellese AA, Vaccaro O, A controlled study of the use of autologous
platelet gel for the treatment of diabetic foot ulcers. Nutr Metab
Cardiovasc Dis. 2004 Dec; 14(6):395-6
Holloway GA, Steed DL, DeMarco MJ, et al. A randomized, controlled
dose response trial of activated platelet supermatant, topical CT-102
in chronic, nonhealing, diabetic wounds. Wounds. 1993;5:160-168.
Steed DL, Goslen JB, Holloway GA, et al. Randomized, double blind
trial in healing of chronic diabetic foot ulcers: CT-102 activated
platelet supernatant, topical versus placebo. Diabetes Care.
1992;15:1598-1604.
Knighton DR, Ciresi K, Fiegel VD, et al. Stimulation of repair in
chronic nonhealing cutaneous ulcers: a prospectively randomized
blinded trial using platelet-derived wound healing formula. Surg
Gynecol Obstet. 1990;170:56-60.
Atri SC, Misra J, Bisht D, et al. Use of homologous platelet factors
in achieving total healing of recalcitrant skin ulcers. Surgery.
1990;108: 508-512
Retrospective Studies
Margolis DJ, Kantor J, Santanna J, et al. Effectiveness of Platelet
Releasate for the Treatment of Diabetic Neuropathic Foot Ulcers.
Diabetes Care. 2001;24:483-488.
Fylling CP, Baxter CR, Bennett KG, et al. Multi-center clinical
review: Using autologous platelet gel for the treatment of diabetic
plantar wounds. Diabetes. 2001(S2);50:229A.
Glover JL, Weingarten MS, Buchbinder DS, et al. A four-year
multicenter retrospective study of topical multiple growth factor
therapy for chronic wounds. Adv Wound Care. 1997;10(1):27-32.
Keyser, JE. Diabetic wound healing and limb salvage in an outpatient
wound care program. South Med Jour. 1993;86:311-317.
Fylling, CP. A five center study of diabetic wound healing in comprehensive wound management programs. Diabetes. 1992(S);41:82A
Knighton DR, Fylling CP, Fiegel VD, et al. Amputation prevention in
an independently reviewed at-risk diabetic population using a
comprehensive wound care protocol. Amer J Surg. 1990;160:466-472.
Fylling CP, Knighton DR, Gordinier RH. The use
of a comprehensive wound care protocol including topical growth factor
therapy in treatment of diabetic neuropathic ulcers. In: Ward J and
Goto Y. Diabetic Neuropathy. New York: John Wiley & Sons; 1990:567-578.
Doucette MM, Fylling CP, Knighton DR. Amputation
Prevention in a high-risk population through a comprehensive wound
healing protocol. Arch Phys Med Rehabil. 1989;70:780-785.
Knighton DR, Fylling CP, Doucette MM. Wound
healing and amputation in a high-risk diabetic population. Wounds.
1989;2:107-114.
Knighton DR, Ciresi KF, Fiegel VD, et al.
Classification and treatment of chronic nonhealing wounds: successful
treatment with autologous platelet-derived wound healing factors (PDWHF).
Ann Surg. 1986;3:322-330..
Cost Effectiveness Studies
Bentkover JF, Champion AH. Economic evaluation of alternative methods
of treatment for diabetic foot ulcer patients: cost effectiveness of
platelet releasate and wound care clinics. Wounds. 1993;5:207-215.
Fylling CP, McKeown PC. Cost and healing efficacy of treating diabetic
foot ulcers in a comprehensive wound management program with growth
factor therapy. Diabetes. 1990(S);39:18A.
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